Influence of Profound Muscle Relaxation on Muscle Trauma and Postoperative Pulmonary Function

Ying Xiao

Status and phase: Unknown; Phase 4

Conditions: Muscle Trauma; Postoperative Analgesic Demand; Postoperative Pulmonary Function; Profound Muscle Relaxation

Treatments: Drug: profound neuromuscular blockade

Study type: Interventional

Funder types: Other

Identifiers

NCT01804933

伦审[2012]326号

Details and patient eligibility

About

Although deep anesthesia can produce skeleton muscle relaxation,unnecessary deep anesthesia often had adverse cardiac effects and was related to 2-year mortality in cancer patients.The use of muscle relaxants allowed the depth of anesthesia to be optimized.However, for many anesthesiologists,in fear of residual postoperative neuromuscular blockade,intraoprative administration of muscle relaxants had to be minimized in spite of poor surgical conditions.

This study, however, is designed to test the hypothesis that profound neuromusclular blockade reduces muscle trauma caused by self-retaining retractor and thus cut down postoperative analgesic requirement.On the other hand,profound muscle relaxation can decrease postoperative diaphragmatic dysfunction and abdominal muscle trauma, which can improve postoperative pulmonary function.

Enrollment: 72 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ASA 1~2,scheduled to undergo upper abdominal surgery by midline incision

Exclusion criteria

• neuromuscular disorder
• history of malignant hyperthemia
• allergy to medications used during general anesthesia

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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72 participants in 3 patient groups

conventional neuromuscular blockade

No Intervention group

Description:

No rocuronium will be administered intraoperatively unless there is surgeons' complain or patients movement

optimal neuromuscular blockade

Active Comparator group

Description:

Rocuronium dose will be infused to maintain depth of NMB at TOF count 1 intraoperatively

Treatment:

Drug: profound neuromuscular blockade

profound neuromuscular blockade

Experimental group

Description:

Rocuronium dose will be infused to maintain a depth of NMB to PTC 1\~2 intraoperatively

Treatment:

Drug: profound neuromuscular blockade