Influence of Protein Hydrolysis on Dietary Protein Digestibility and Metabolism in Healthy Subjects

I

Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement

Status

Completed

Conditions

Healthy

Treatments

Dietary Supplement: 15N-labelled intact casein
Dietary Supplement: mixture of AA
Dietary Supplement: 15N-labelled hydrolyzed casein
Other: Intestinal and metabolic exploration

Study type

Interventional

Funder types

Other

Identifiers

NCT00873951
DEGLAIRE CT

Details and patient eligibility

About

Hydrolysis of dietary protein may impact their gastrointestinal kinetics and further metabolism. The primary goal of this work was to measure the metabolic fate of intact or hydrolyzed protein using a protein of good nutritional quality, i.e., casein. A second aim of this study was to assess the true ileal digestibility of dietary protein using different methods including the hydrolyzed casein method and to measure its possible effect on endogenous intestinal N losses in humans.

Enrollment

26 patients

Sex

All

Ages

18 to 40 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • healthy subjects
  • BMI between 18 and 25

Exclusion criteria

  • allergy to dairy proteins
  • positive serology to AgHbS, HCV or HIV
  • pregnancy
  • abusive drug or alcohol consumption.

Trial design

26 participants in 3 patient groups

Intact casein
Experimental group
Description:
Subjects undergo an intestinal and metabolic exploration following the ingestion of a standard mixed meal containing 15% of energy as 15N-labelled intact casein
Treatment:
Other: Intestinal and metabolic exploration
Dietary Supplement: 15N-labelled intact casein
Hydrolyzed casein
Experimental group
Description:
Subjects undergo an intestinal and metabolic exploration following the ingestion of a standard mixed meal containing 15% of energy as 15N-labelled hydrolyzed casein
Treatment:
Dietary Supplement: 15N-labelled hydrolyzed casein
Other: Intestinal and metabolic exploration
AA
Experimental group
Description:
Subjects undergo an intestinal and metabolic exploration following the ingestion of a standard mixed meal containing 15% of energy as a mixture of AA mimicking the composition of casein but devoid in serine
Treatment:
Other: Intestinal and metabolic exploration
Dietary Supplement: mixture of AA

Trial contacts and locations

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Data sourced from clinicaltrials.gov

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