Influence of Pupillary Behavior During Eye Surgery on Morphological and Functional Outcome

Klinikum Klagenfurt am Wörthersee

Status: Enrolling

Conditions: Vitreous Disorder; Cataract; Corneal Disease

Treatments: Other: OCT Scan, Video of pupil movement, video of toric lens

Study type: Observational

Funder types: Other

Identifiers

NCT06160960

A 28/17

Details and patient eligibility

About

Pupillary movement during eye surgery can be a challenge for eye surgeons. Despite the risk of intraocular lens damage and malpositioning due to mechanical manipulation1, iris manipulation may lead to a significant elevation of cytokines in the aqueous humor and an increase of postoperative inflammation2, 3. Iris damage is also known to lead to an increase of prostaglandin production which will not only lead to an increase of inflammation but also has an impact on intraoperative miosis4. This leads to the assumption that postoperative inflammation can be related to intraoperative pupillary movements due to the same leading cause of an increase of inflammatory mediators. Tracking intraoperative pupillary movements might therefore be a helpful tool for the prediction of postoperative PCME and could have an impact on therapeutic decisions after surgery.

Enrollment: 500 estimated patients

Sex: All

Ages: 18 to 120 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• presence of significant cataract,
• written consent.
• presence of other ocular conditions requiring surgery such as: degenerative corneal disease, retinal conditions (i.e. macular pucker)

Exclusion criteria

• reasons for poor video quality (such as poor red reflex due to abnormal anatomy)