Influence of Rapeseed Proteins on the Postprandial Metabolic Response

Martin-Luther-Universität Halle-Wittenberg

Status: Completed

Conditions: Health, Subjective

Treatments: Dietary Supplement: rapeseed or soy protein or no protein

Study type: Interventional

Funder types: Other

Identifiers

NCT03620812

UFOP 062018

Details and patient eligibility

About

The aim of the study is to investigate the effect of rapeseed proteins on the postprandial metabolic response. Therefore, study participants will receive a meal rich in fat and carbohydrates with and without rapeseed protein or with soy protein that serves as control.

Full description

The current study is a monocentric, controlled intervention study that will be conducted as cross-over design. Three interventions are planned and participants will be invited to consume a test meal with added rapeseed protein isolate, a test meal with added soy protein isolate and a test meal without additional protein. The evening before, the subjects will receive a standardized dinner. After a 12-hour fasting overnight, a cannula will be placed. Blood samples will be taken before and after eating the test meal rich in carbohydrate and fat. The test meal consists of pasta with oily tomato sauce with either 25 g of rapeseed protein, 25 g of soy protein or no additional protein. A total of 11 blood samples will be collected over a period of 6 hours. In the meantime, the blood pressure and pulse will be measured repeatedly and information on satiety will be recorded. The interventions will be interrupted by a period of, at least, 2 weeks.

Enrollment: 20 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy men and women
• age between 18 and 65 years
• informed consent
• body mass index between 18,5 up to 29,9 kg/m2
• anamnesis without diagnostic findings

Exclusion criteria

• acute or chronic diseases ((hypertension, coronary diseases, renal diseases, diabetes, alcohol abuse etc.)
• intake of drugs (exemption: oral contraceptive)
• pregnancy or lactation
• food intolerance or allergies to mustard, soy, tomato, wheat
• participation on another trial
• blood donation - while last 2 month before the start of the study
• extensive physical activity (competitive sports, hard physical work)
• diet procedure
• smoking

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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20 participants in 3 patient groups, including a placebo group

rapeseed protein

Experimental group

Description:

Three interventions are planned, in which the subjects will eat a test meal with added rape protein isolate (arm 1), a test meal with added soy protein isolate (arm 2) and a test meal without additional protein (arm 3) in random order on 3 days. The subjects are randomly assigned to one of the 3 treatment arms, ultimately resulting in 6 sequences (cross-over)

Treatment:

Dietary Supplement: rapeseed or soy protein or no protein

soy protein

Active Comparator group

Treatment:

Dietary Supplement: rapeseed or soy protein or no protein

no protein

Placebo Comparator group

Treatment:

Dietary Supplement: rapeseed or soy protein or no protein