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Influence of Remifentanil on Postoperative Sore Throat in Patients Undergoing General Anesthesia

K

Keimyung University

Status

Completed

Conditions

Hip Arthroplasty

Treatments

Procedure: Endotracheal intubation using laryngoscope
Drug: Low sevoflurane
Drug: High sevoflurane
Drug: Low remifentanil
Drug: High remifentanil

Study type

Interventional

Funder types

Other

Identifiers

NCT03173339
HighRemiSoreThroat

Details and patient eligibility

About

This investigation is planned to compare the incidence and severity of postoperative sore throat according to the dose of remifentanil.

Enrollment

92 patients

Sex

All

Ages

18 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • ASA I-III
  • Patients scheduled for general anesthesia with endotracheal intubation

Exclusion criteria

  • Difficult airway
  • Rapid sequence induction
  • Recent sore throat
  • Recent upper respiratory infection
  • Asthma
  • Chronic obstructive pulmonary disease
  • Chronic cough
  • Pregnancy
  • Allergy to remifentanil
  • Friable teeth
  • History of head and neck surgery
  • Multiple intubation attempts
  • Regional anesthetic agents
  • Gastric tube
  • Dexamethasone

Trial design

Primary purpose

Prevention

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Triple Blind

92 participants in 2 patient groups

Low remifentanil and high sevoflurane
Active Comparator group
Description:
Remifentanil was administered as 0.1 mcg/kg/min. Sevoflurane was started as 0.5 MAC. Sevoflurane dose was adjusted to maintain blood pressure (20% of preoperative blood pressure) and bispectral index (40-60) by 0.2 %.
Treatment:
Drug: High sevoflurane
Drug: Low remifentanil
Procedure: Endotracheal intubation using laryngoscope
High remifentanil and low sevoflurane
Experimental group
Description:
Sevoflurane was administered as 0.5 MAC. Remifentanil was started as 0.25 mcg/kg/min. Remifentanil dose was adjusted to maintain blood pressure (20% of preoperative blood pressure) and bispectral index (40-60) by 0.05 mcg/kg/min.
Treatment:
Procedure: Endotracheal intubation using laryngoscope
Drug: Low sevoflurane
Drug: High remifentanil

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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