Influence of Remifentanil on Postoperative Sore Throat in Patients Undergoing General Anesthesia

Keimyung University

Status: Completed

Conditions: Hip Arthroplasty

Treatments: Procedure: Endotracheal intubation using laryngoscope; Drug: Low sevoflurane; Drug: High sevoflurane; Drug: Low remifentanil; Drug: High remifentanil

Study type: Interventional

Funder types: Other

Identifiers

NCT03173339

HighRemiSoreThroat

Details and patient eligibility

About

This investigation is planned to compare the incidence and severity of postoperative sore throat according to the dose of remifentanil.

Enrollment: 92 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ASA I-III
• Patients scheduled for general anesthesia with endotracheal intubation

Exclusion criteria

• Difficult airway
• Rapid sequence induction
• Recent sore throat
• Recent upper respiratory infection
• Asthma
• Chronic obstructive pulmonary disease
• Chronic cough
• Pregnancy
• Allergy to remifentanil
• Friable teeth
• History of head and neck surgery
• Multiple intubation attempts
• Regional anesthetic agents
• Gastric tube
• Dexamethasone

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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92 participants in 2 patient groups

Low remifentanil and high sevoflurane

Active Comparator group

Description:

Remifentanil was administered as 0.1 mcg/kg/min. Sevoflurane was started as 0.5 MAC. Sevoflurane dose was adjusted to maintain blood pressure (20% of preoperative blood pressure) and bispectral index (40-60) by 0.2 %.

Treatment:

Drug: High sevoflurane

Drug: Low remifentanil

Procedure: Endotracheal intubation using laryngoscope

High remifentanil and low sevoflurane

Experimental group

Description:

Sevoflurane was administered as 0.5 MAC. Remifentanil was started as 0.25 mcg/kg/min. Remifentanil dose was adjusted to maintain blood pressure (20% of preoperative blood pressure) and bispectral index (40-60) by 0.05 mcg/kg/min.

Treatment:

Procedure: Endotracheal intubation using laryngoscope

Drug: Low sevoflurane

Drug: High remifentanil