Influence of Serum Sodium Levels on Bone Metabolism and Turnover in Hospitalized Patients (BONA)

University Hospital Basel

Status: Completed

Conditions: Hyponatremia

Treatments: Other: blood sampling

Study type: Observational

Funder types: Other

Identifiers

NCT04227301

2019-01858 me18ChristCrain6;

Details and patient eligibility

About

In this study, the possible role of serum sodium concentration and its changes on bone markers in hospitalized, hyponatremic patients is determined. Therefore, it is investigated whether in hospitalized, hyponatremic patients the level of carboxy-terminal collagen crosslinks (CTX) is modified by changes in plasma sodium concentration, independently from the aetiology of hyponatremia.

Enrollment: 52 patients

Sex: All

Ages: 18 to 99 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult hospitalized patients with non-hypertonic hyponatremia: serum sodium < 130 mmol/l, serum osmolality < 300 milliosmol /kg
• age 18 to 99-year-old
• Informed consent as documented by signature

Exclusion criteria

• Severe symptomatic hyponatremia in need of intensive care treatment
• Hypertonic hyponatremia with serum osmolality > 300 mOsm/kg
• End of life care (palliative treatment)
• End stage kidney disease (dialysis)
• Acute liver failure
• Wernicke encephalopathy
• Hepatic encephalopathy during last 2 months
• Hepato-renal syndrome
• Any bone disease requiring treatment in the last three years
• History of fragility fractures
• Pre-menopausal women
• Hypogonadism (diagnosed before hospitalization)
• Hyperthyroidism
• Steroid therapy

Trial design

52 participants in 1 patient group

Hyponatremic patients

Description:

Patients hospitalized at the University Hospital of Basel and presenting with hyponatremia will be screened for the study

Treatment:

Other: blood sampling