Influence of Sevoflurane and Desflurane on Postoperative Sore Throat

Keimyung University

Status: Unknown

Conditions: Hip Arthroplasty

Treatments: Drug: Desflurane; Drug: Sevoflurane

Study type: Interventional

Funder types: Other

Identifiers

NCT03259672

SevoDesPOST

Details and patient eligibility

About

This investigation is planned to compare the incidence and severity of postoperative sore throat according to the use of sevoflurane or desflurane.

Enrollment: 100 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ASA I-III
• Patients scheduled for general anesthesia with endotracheal intubation

Exclusion criteria

• Difficult airway
• Friable teeth
• Rapid sequence induction
• Recent sore throat
• Recent upper respiratory infection
• Asthma
• Chronic obstructive pulmonary disease
• Chronic cough
• Arrhythmia
• Coronary disease
• Heart failure
• Pregnancy
• Allergy to sevoflurane
• Allergy to desflurane
• Fever after halogenated anesthetics
• Jaundice after halogenated anesthetics
• Malignant hyperthremia
• Allergy to remifentanil
• Friable teeth
• History of head and neck surgery
• Multiple intubation attempts
• Regional anesthetic agents
• Gastric tube
• Dexamethasone
• Severe hypovolemia

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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100 participants in 2 patient groups

Sevoflurane

Active Comparator group

Treatment:

Drug: Sevoflurane

Desflurane

Experimental group

Treatment:

Drug: Desflurane