Influence of Stroke on the Composition of Intestinal Microbiota (GUTSTROKE)

Charité University Medicine Berlin

Status: Completed

Conditions: Stroke; Transient Ischemic Attack (TIA)

Study type: Observational

Funder types: Other

Identifiers

NCT02008604

GUTSTROKE

Details and patient eligibility

About

The aim of the study is to verify the hypothesis that the microbial colonisation of the gut is changed in patients after stroke and that the gut microbiome of severely affected stroke patients differs from that of patients with only a short disruption of blood circulation in the brain (transient ischemic attack, TIA). For this, the composition of gut microbiota in stool samples will be analyzed by 454 pyrosequencing. Further, the correlation of stroke-associated changes in the microbiome with immunological parameters will be analyzed.

Enrollment: 24 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age: 18 and older
• ischemic cerebral infarction within the last 40 hours, anterior circulation infarct (ACA, MCA) and/or posterior circulation infarct (PCA, BA) of any severity
• patient consent or consent by a legal representative
• NIHSS > or =9 (stroke patients)
• NIHSS < 1 (for TIA patients)

Exclusion criteria

• intracranial hemorrhage
• preexisting dysphagia
• signs of infection upon admission (clinical/paraclinical)
• existing antibiotic therapy upon admission or within the last 2 weeks before admission
• mechanical ventilation upon admission
• participation in an interventional therapy study

Trial design

24 participants in 2 patient groups

Stroke patients

TIA patients

Description:

patients with a transient ischemic attack (control group)