Influence of tDCS on Cortical Plasticity in Healthy Older Adults

Charité University Medicine Berlin

Status: Withdrawn

Conditions: Healthy Older Adults

Treatments: Device: sham stimulation; Device: transcranial direct current stimulation

Study type: Interventional

Funder types: Other

Identifiers

NCT01888055

Plasticity in healthy adults

Details and patient eligibility

About

The aim of this study is to investigate whether the anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) in healthy older adults leads to an increase in cortical plasticity (change in motor evoked potentials (MEP) in mV).

Sex: All

Ages: 50 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• right-handed according to the Oldfield Händigkeits inventory (lateralization index >70)(1971)
• no obvious cognitive impairment (MMSE>26, Demtect>13)
• age between 50 and 80 years

Exclusion criteria

• Severe neurological / psychiatric or pre-existing internist conditions because additional cognitive deficits are expected
• Epilepsy, epileptic seizure in medical history
• Cognitive deficit (MMSE <20)
• Depressive episode (Beck Depression Inventory (BDI) > 12)
• intake of centrally active drugs <3 months , particularly acetylcholinesterase inhibitors
• Pregnancy
• Pacemaker (contraindication for MRI)
• Other metal parts in the body (contraindication for MRI)

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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0 participants in 2 patient groups, including a placebo group

transcranial direct current stimulation

Experimental group

Treatment:

Device: transcranial direct current stimulation

sham stimulation

Placebo Comparator group

Treatment:

Device: sham stimulation