Influence of tDCS on Cortical Plasticity in Patients With Mild Cognitive Impairment (MCI)

Charité University Medicine Berlin

Status

Withdrawn

Conditions

Patients With Mild Cognitive Impairment

Treatments

Device: sham stimulation

Device: transcranial direct current stimulation

Study type

Interventional

Funder types

Other

Identifiers

NCT01888029

Plasticity in MCI

Details and patient eligibility

About

The aim of this study is to investigate whether the anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) in patients with mild cognitive impairment (MCI) leads to an increase in cortical plasticity (change in motor evoked potentials (MEP) in mV).

Sex

All

Ages

50 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Right-handed according to the Oldfield Händigkeits inventory (lateralization index> 70) (1971)
Cognitive impairment according to the diagnostic criteria of a MCI (amnesic or even multiple domains)
No therapeutic treatment with AChE inhibitors
No motor impairments relevant to everyday life
Age 50 to 80 years

Exclusion criteria

Severe neurological / psychiatric or pre-existing internist conditions because additional cognitive deficits are expected
Epilepsy, epileptic seizure in medical history
Cognitive deficit (MMSE <20)
Depressive episode (Beck Depression Inventory (BDI)> 12)
Newly taking (<3 months) centrally active drugs, particularly acetylcholinesterase inhibitors
Pregnancy
Pacemaker (contraindication for MRI)
Other metal parts in the body (contraindication for MRI)