Influence of tDCS on Cortical Plasticity in Patients With Mild Cognitive Impairment (MCI)

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Charité University Medicine Berlin

Status

Withdrawn

Conditions

Patients With Mild Cognitive Impairment

Treatments

Device: sham stimulation
Device: transcranial direct current stimulation

Study type

Interventional

Funder types

Other

Identifiers

NCT01888029
Plasticity in MCI

Details and patient eligibility

About

The aim of this study is to investigate whether the anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) in patients with mild cognitive impairment (MCI) leads to an increase in cortical plasticity (change in motor evoked potentials (MEP) in mV).

Sex

All

Ages

50 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Right-handed according to the Oldfield Händigkeits inventory (lateralization index> 70) (1971)
  • Cognitive impairment according to the diagnostic criteria of a MCI (amnesic or even multiple domains)
  • No therapeutic treatment with AChE inhibitors
  • No motor impairments relevant to everyday life
  • Age 50 to 80 years

Exclusion criteria

  • Severe neurological / psychiatric or pre-existing internist conditions because additional cognitive deficits are expected
  • Epilepsy, epileptic seizure in medical history
  • Cognitive deficit (MMSE <20)
  • Depressive episode (Beck Depression Inventory (BDI)> 12)
  • Newly taking (<3 months) centrally active drugs, particularly acetylcholinesterase inhibitors
  • Pregnancy
  • Pacemaker (contraindication for MRI)
  • Other metal parts in the body (contraindication for MRI)

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Double Blind

0 participants in 2 patient groups, including a placebo group

transcranial direct current stimulation
Experimental group
Treatment:
Device: transcranial direct current stimulation
sham stimulation
Placebo Comparator group
Treatment:
Device: sham stimulation

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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