Influence of Thymoglobuline on Phenotypic and Functional Profiles of B Lymphocytes in Renal Transplant Recipients (THYMO B)

Regional University Hospital Center (CHRU)

Status: Unknown

Conditions: Renal Transplant

Treatments: Drug: Basiliximab Induction; Drug: Thymoglobulin Induction

Study type: Observational

Funder types: Other

Identifiers

NCT02894606

THYMO B (RB 13.072)

Details and patient eligibility

About

The investigators expect to better characterise B cell subpopulation and functional properties early after graft, to analyse effect of induction therapy (thymoglobulin versus basiliximab) on B cells, and to compare this B cell profiles with those obtained in our previous study in patients with chronic Antibody Mediated Rejection (cAMR)

Enrollment: 40 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age >18 years old
• Recipient of a renal allograft
• Patient receiving either basiliximab or thymoglobulin as in induction therapy for renal transplant
• Patient presenting a low immunologic risk
• Patient not opposed to his (her) study participation

Exclusion criteria

• Patient participating in a clinical trial

Trial design

40 participants in 2 patient groups

Thymoglobulin Induction

Description:

Patient receiving thymoglobulin as an induction therapy for renal transplant

Treatment:

Drug: Thymoglobulin Induction

Basiliximab Induction

Description:

Patient receiving basiliximab as an induction therapy for renal transplant

Treatment:

Drug: Basiliximab Induction