Influence of Tightly Glucose Control on Hyperglycemic Toxicity and Protein Catabolism in Critically Ill Patients

Kaohsiung Veterans General Hospital

Status and phase

Completed

Phase 3

Conditions

Critically Ill Patients

Treatments

Other: Tightly glucose control

Other: Conventional glucose control

Study type

Interventional

Funder types

Other

Identifiers

NCT01227148

VGHKS95-070

Details and patient eligibility

About

To compare the differences of urinary nitrogen excretion, nitrogen balance and clinical outcomes between tightly insulin therapy and conventional insulin therapy in the ICU.

Full description

Critical illness is associated with increased circulating concentrations of proinflammatory cytokines, such as tumor necrosis factor (TNF-α), interleukin (IL)-1, and IL-6 which may be important mediators of insulin resistance and results in hyperglycemia. Altered glucose metabolism was caused by release of counter regulatory hormones such as glucagons; epinephrine and cortisol oppose the normal action of insulin, leading to an increase in skeletal muscle proteolysis. It did not know whether tightly glucose control had beneficial effect in urinary nitrogen excretion and nitrogen balance.

Enrollment

112 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Patients admitted to the adult ICU who had baseline blood glucose > 180 mg/dl
expected to require treatment in the ICU on 3 or more consecutive days.

Exclusion criteria

pregnant patients
patients with chronic renal loss (Chronic renal loss was defined as persistent acute renal failure, complete loss of kidney function > 4 weeks)