Influence of Tobacco Use on Cannabis Use

New York State Psychiatric Institute

Status and phase: Suspended; Phase 2

Conditions: Cannabis Use; Tobacco Use

Treatments: Drug: Cannabis; Behavioral: 21 days of Tobacco Cessation; Behavioral: 7 days of Tobacco Cessation

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT03766971

7707 (Other Identifier)

Details and patient eligibility

About

Cannabis smokers who also smoke tobacco cigarettes have markedly higher rates of cannabis relapse relative to those who do not use tobacco. There is a clear need to develop and evaluate interventions for dual tobacco and cannabis users. The investigators of this study have previously shown that the co-use of tobacco cigarettes contributes to the maintenance of daily cannabis use, and that age of cigarette onset is a critical predictor of treatment outcome. Short-term tobacco cessation may suffice in altering cannabis relapse rates in later-onset cigarette smokers, while a longer period of tobacco cessation may be needed for earlier-onset smokers. In the current study, a human laboratory model will be utilized to determine whether cannabis relapse varies as a function of tobacco cessation duration and age of tobacco use onset.

Enrollment: 160 estimated patients

Sex: All

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Males and non-pregnant females aged 18-60 years old
• Use cannabis
• Smoke tobacco cigarettes
• Medically and psychologically healthy

Exclusion criteria

• Regular drug use other than cannabis
• Current pregnancy/lactation

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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160 participants in 2 patient groups

Early-onset Cigarette Smokers

Experimental group

Description:

Participants who began smoking cigarettes earlier in life (\<16 years old) will be randomized to 7 or 21 days of tobacco cessation.

Treatment:

Behavioral: 7 days of Tobacco Cessation

Behavioral: 21 days of Tobacco Cessation

Drug: Cannabis

Late-onset Cigarette Smokers

Experimental group

Description:

Participants who began smoking cigarettes later in life (\>16 years old) will be randomized to 7 or 21 days of tobacco cessation.

Treatment:

Behavioral: 7 days of Tobacco Cessation

Behavioral: 21 days of Tobacco Cessation

Drug: Cannabis