Influence of Treatment for Patent Ductus Arteriosus on Cerebral Oxygenation in Preterm Infants

University of Ulm

Status

Completed

Conditions

Prematurity of Fetus

Patent Ductus Arteriosus

Treatments

Drug: Ibuprofen

Procedure: Surgical Ligation

Drug: Indomethacin

Study type

Observational

Funder types

Other

Identifiers

NCT01428180

ULMNEONIRS03

Details and patient eligibility

About

The purpose of this study is to examine the influence medical or surgical treatment for patent ductus arteriosus in preterm infants on cerebral and renal tissue oxygenation and on cardiac output.

Full description

In this observational trial the investigators want to examine whether clinical or echocardiographic parameters of patent ductus arteriosus are related to

cerebral tissue oxygen saturation, total hemoglobin, fractional tissue oxygen extraction and HbD
renal tissue oxygen saturation, total hemoglobin, fractional tissue oxygen extraction and HbD

as measured by near infrared spectroscopy

and to

stroke volume
cardiac output

as measured by electrical cardiometry.

The investigators want to examine the impact of surgical and medical treatment for patent ductus on these parameters. The investigators want to compare the change of these parameters between responders to medical treatment and nonresponders.

Enrollment

35 patients

Sex

All

Ages

Under 34 weeks old

Volunteers

No Healthy Volunteers

Inclusion criteria

Newborn infant below 34 weeks postmenstrual age at the time of birth
Patent ductus arteriosus with signs of hemodynamic relevance (as judged by the attending neonatologist)
parental informed consent

Exclusion criteria