Influence of TyG Index and TG/HDL-C Ratio on Fetal Macrosomia

Ankara Etlik City Hospital

Status

Completed

Conditions

Fetal Macrosomatia

Hyperlipidemias

Lipid Metabolism Disorders

Treatments

Other: TyG index

Study type

Observational

Funder types

Other

Identifiers

NCT06463990

AECH-FIRATLIGIL-001

Details and patient eligibility

About

Metabolic disorders that can occur during pregnancy, in particular disorders of lipid metabolism and insulin resistance, can have a detrimental effect on pregnancy and the fetus.

The triglyceride level and other lipids increase slightly during pregnancy. This increase has a positive effect on the development of the fetus. However, an excessive increase in lipid levels can cause some metabolic disorders such as gestational diabetes and increase feto-maternal morbidity/mortality.

While some existing studies have shown that elevated triglyceride levels can cause fetal macrosomia, others have found no correlation between these two variables. The ratio of triglycerides to HDL is a widely used marker for lipid disorders. In addition, the triglyceride-glucose index is also an index used to detect insulin resistance.

Full description

In this study, the investigators aimed to investigate whether the ratio of triglycerides to high-density lipoprotein cholesterol and the triglyceride glucose index are associated with fetal macrosomia in low-risk nulliparous pregnant women.

Enrollment

302 patients

Sex

Female

Ages

18 to 40 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Screening for fetal macrosomia was based on the term defined according to the standards of the American College of Obstetricians and Gynecologists (ACOG).
Low-risk nulliparous singleton pregnant women.
Age between 18 and 40 years old

Exclusion criteria

Post-term pregnancies
Hospitalized for preterm labor or preterm premature rupture of membranes.
Gestational diabetes mellitus, diabetes mellitus type I - type II.
Pregnant women with fetal growth restriction, hypertensive pregnancy disorders, familial hypercholesterolemia and hyperlipidemia.
Multiparous pregnant women
Multiple pregnancies
Pregnant women with chronic diseases.
Pregnant women with impaired liver function;
Pregnant women with body mass index <25 and >40 kg/m2.