Influence Positive End-expiratory Pressure on Autoregulation in Patients With Respiratory Insufficiency (dARICUPEEP)

Johannes Gutenberg University (JGU)

Status: Completed

Conditions: Respiratory Insufficiency

Treatments: Procedure: positive end-expiratory pressure

Study type: Observational

Funder types: Other

Identifiers

NCT01376518

837.041.10 1

Details and patient eligibility

About

The aim of the present study is to characterize the influence of an elevated positive end-expiratory pressure in patients with acute respiratory distress syndrome or acute lung injury on the cerebrovascular autoregulation.

Full description

Cerebral blood flow velocity will be measured using transcranial Doppler sonography and then correlate with the invasive arterial blood pressure curve to calculate the index of cerebrovascular autoregulation Mx (Mx>0.3 indicates impaired AR). The index of cerebrovascular autoregulation Mx was measured during baseline positive end-expiratory pressure (PEEP) levels and after lung recruitment with higher level of PEEP. The equality between this two PEEP levels was estimated and calculated with one side Wilcoxon test.

Enrollment: 20 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• respiratory failure
• Age >18 years
• Invasive ventilation

Exclusion criteria

• Sepsis
• preexisting cerebral illness
• traumatic brain injury
• meningitis or encephalitis
• pregnancy

Trial design

20 participants in 1 patient group

respiratory failure

Description:

patients with respiratory failure and need of high positive end-expiratory pressure ventilation.

Treatment:

Procedure: positive end-expiratory pressure