Influences of Long Term Hormone Therapy on Physical Fitness and Vascular Function in Transgender Women

Chulalongkorn University

Status: Completed

Conditions: Transgender Women

Treatments: Other: Estradiol; Other: No intervention; Other: Estradiol and Anti-Androgen

Study type: Interventional

Funder types: Other

Identifiers

NCT06116201

SPSC-7

Details and patient eligibility

About

Transgender women who transitioned from male to female by hormone therapy demonstrate similar physical fitness and vascular function to males or females.

Full description

This cross-sectional study was to compare physical fitness and vascular function between cisgender men, cisgender women, and transgender women.

Enrollment: 60 patients

Sex: All

Ages: 20 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Cisgender men group (Body mass index between 18.5-24.9 and NO NCDs).
2. Cisgender women group (Body mass index between 18.5-24.9, No pregnant, NO NCDs).
3. Transgender women with orchiectomy (Body mass index between 18.5-24.9, taking estradiol, testosterone level below 10 nmol/L, NO NCDs).
4. Transgender women without orchiectomy (Body mass index between 18.5-24.9, taking estradiol and anti-androgen, testosterone level below 10 nmol/L, NO NCDs).

Exclusion criteria

• Participants had an injury during testing.

Trial design

Primary purpose: Screening

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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60 participants in 4 patient groups

Transgender women with orchiectomy

Experimental group

Description:

Transgender women who took medication for sex transition form male to female via estradiol hormone therapy and orchiectomy surgery. They were recruited for measurement of all variables in the study to compare with another group.

Treatment:

Other: Estradiol

Transgender women without orchiectomy

Experimental group

Description:

Transgender women who took medication for sex transition form male to female via estradiol hormone and anti-androgen hormone therapy. They were recruited for measurement of all variables in the study to compare with another group.

Treatment:

Other: Estradiol and Anti-Androgen

Cisgender men

Sham Comparator group

Description:

Cisgender men who lived in normal life were not used medication process for sex transition. They were recruited for measurement of all variables in the study to compare with another group.

Treatment:

Other: No intervention

Cisgender women

Sham Comparator group

Description:

Cisgender women who lived in normal life were not used medication process for sex transition. They were recruited for measurement of all variables in the study to compare with another group.

Treatment:

Other: No intervention