Influences of Phenylephrine, Dopamine and Ephedrine on Stroke Volume Variation and Pulse Pressure Variation

Chinese PLA General Hospital (301 Hospital)

Status: Completed

Conditions: Circulation; Calculated SAP; Drug Dose

Treatments: Other: Influences of phenylephrine, dopamine and ephedrine on stroke volume variation and pulse pressure variation

Study type: Interventional

Funder types: Other

Identifiers

NCT02201121

plaghran001

Details and patient eligibility

About

Although induced hypertension decreased SVV and PPV,the influences of stroke volume variation and pulse pressure variation caused by phenylephrine,dopamine and ephedrine were unknown.

Full description

Pulse pressure variation (PPV) and stroke volume variation (SVV) during mechanical ventilation have been shown to be effective parameters to predict preload responsiveness. Although induced hypertension decreases PPV and SVV, the influences of phenylephrine, dopamine and ephedrine on PPV and SVV are unknown.

Enrollment: 94 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Their American Society of Anesthesiologists (ASA) physical status was 1 or 2
• Body mass index (BMI) ranged from 18 to 26
• None of the patients had known diabetes mellitus, hypertension, cardiovascular, pulmonary, endocrinological, neurological diseases, or diseases that influenced intravascular fluid volume or balance
• All patients had a preoperative fast for at least 8 h and routine atropine intramuscular injection

Exclusion criteria

• Persistent arrhythmias
• Intraoperative application of vasoactive drugs except phenylephrine, dopamine and ephedrine

Trial design

94 participants in 1 patient group

phenylephrine group, dopamine group, ephedrine group

Experimental group

Description:

phenylephrine group: use the phenylephrine to increase the SAP from low to high level. dopamine group: use the dopamine to increase the SAP from low to high level. ephedrine group:use the ephedrine to increase the SAP from low to high level.

Treatment:

Other: Influences of phenylephrine, dopamine and ephedrine on stroke volume variation and pulse pressure variation