Influencing Factors of the Diagnostic Accuracy of Novel Coronary Functional Evaluation Methods

Peking University

Status: Not yet enrolling

Conditions: Coronary Heart Disease

Study type: Observational

Funder types: Other

Identifiers

NCT06178133

M2023683

Details and patient eligibility

About

In this study, patients were retrospectively included, univariate and multivariate analysis of factors affecting their diagnosis inconsistencies was performed, and a new diagnostic model was constructed by logistic regression.

Full description

The evaluation of coronary function is becoming more and more important in the guidelines, in which coronary flow reserve (FFR) is the gold standard for diagnosis, but its measurement process requires the application of adenosine, vasodilator, etc. Some patients cannot be measured because of asthma and low blood pressure. A new instantaneous wave-free ratio (iFR), contrastive flow reserve fraction (cFFR) and quantitative flow fraction (QFR) have been developed for the evaluation of coronary function. However, in some patients, the new coronary function evaluation methods were inconsistent with FFR. In this study, patients were retrospectively included, univariate and multivariate analysis of factors affecting their diagnosis inconsistencies was performed, and a new diagnostic model was constructed by logistic regression.

Enrollment: 500 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age above 18 and below 80 years old, regardless of gender;
• FFR was detected by coronary angiography;
• The coronary angiography images were clear, meeting the requirements of QFR analysis or detecting iFR, cFFR, and resting pd/pa during the operation.

Exclusion criteria

• 1. Coronary artery bypass graft (CABG);
• 2. Atrial fibrillation or flutter;
• 3. Left or right coronary opening lesions;
• 4. Pregnancy or breastfeeding.

Trial design

500 participants in 1 patient group

FFR

Description:

In this single-center cross-sectional study, we included patients with non-acute myocardial infarction who were admitted to the Department of Cardiology at Peking University Third Hospital for FFR testing from January 2019 to December 2021.