Infusion Laboratory: Protocol 5 (Flupenthixol) - 14

National Institutes of Health (NIH)

Status and phase: Unknown; Phase 1

Conditions: Cocaine-Related Disorders

Treatments: Drug: Flupenthixol

Study type: Interventional

Funder types: NIH

Identifiers

NCT00000349

NIDA-3-0010-14

Y01-3-0010-14

Details and patient eligibility

About

The purpose of this study is to evaluate clinical safety issues pertaining to flupenthixol, to cocaine, and to their interaction, and to determine how pretreatment with flupenthixol modifies the subjective as well as physiological effects of cocaine. Taken together, these relatively D-1 selective agents can help determine the extent to which DA-1 binding affects the reinforcing effects of stimulants.

Sex: All

Ages: 21 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

M/F, ages 21-50. Meet DSM-IV criteria for cocaine dependence. Agree to conditions of the study and sign informed consent.

Exclusion criteria

Psychiatric disorder that requires medication therapy. History of seizures. Pregnant and/or nuring women. Dependence on ETOH or benzodiazepines or other sedative/hypnotics. Acute hepatitis. Other medical condtions that deem participation to be unsafe.