Ingestion of Lipids and Changes in Cerebral Blood Flow of People With Obesity

University of Sao Paulo

Status: Completed

Conditions: Obesity

Treatments: Other: 60 grams of fat plus water solution; Other: Pure water

Study type: Interventional

Funder types: Other

Identifiers

NCT02079116

Process HCRP: 14080/2011

CAAE - 0335.0.004.000-11 (Registry Identifier)

Details and patient eligibility

About

This study aims to determine changes in cerebral blood flow of people with obesity after the ingestion of fat.

Enrollment: 20 patients

Sex: Female

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Live in Ribeirão Preto, São Paulo - Brazil.
• Regular menses.
• Weight inferior than 120 Kg and body mass index (BMI) between 30 and 40 kg/m2, for the group with obesity.
• BMI between 18,5 and 24,9 kg/m2, for the group without obesity.

Exclusion criteria

• High blood pressure, diabetes, glucose intolerance or impaired fasting glycemia, metabolic syndrome, hypothyroidism and any kidney, liver, heart or neurologic disease.
• Psychiatric disorders, alcoholism, smoking or illicit drug abuse.
• Pregnancy or desire to be pregnant
• Use of medications, excluding contraceptives.
• Contraindication for magnetic resonance imaging.
• Be in treatment for obesity.

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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20 participants in 2 patient groups, including a placebo group

60 grams of fat plus water solution

Experimental group

Description:

In the group with 10 volunteers with obesity, some of them are submitted first to the 60 grams of fat plus water solution (meal challenge) and in another time to only water. Also, in the group with 10 volunteers without obesity, some of them are submitted first to the 60 grams of fat plus water solution (meal challenge) and in another time to only water.

Treatment:

Other: Pure water

Other: 60 grams of fat plus water solution

Pure water.

Placebo Comparator group

Description:

In the same group with 10 volunteers with obesity, some of them are submitted first to only water (control) and in another time to the 60 grams of fat plus water solution (meal challenge). Also, in the same group with 10 volunteers without obesity, some of them are submitted first to only water (control) and in another time to the 60 grams of fat plus water solution (meal challenge).

Treatment:

Other: Pure water

Other: 60 grams of fat plus water solution