Inhalation of Lidocaine Before Intubation

New Taipei City Hospital

Status: Unknown

Conditions: Sore Throat

Treatments: Drug: Lidocaine inhalation; Drug: Placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT01838993

CS 2013011

Details and patient eligibility

About

We investigate the potential benefits of ultrasound-driven lidocaine inhalation immediately before induction.

Full description

Sudden increases in blood pressure and heart rate after tracheal intubation and post-operative sore throat are two common undesirable side effects of general anesthesia and might lead to patients' morbidity or dissatisfaction. We investigated the possibility to attenuate both side effects with one single method, i.e. ultrasound-driven lidocaine inhalation immediately before induction.

Enrollment: 70 estimated patients

Sex: All

Ages: 20 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• American Society of Anesthesiologists (ASA) physical status I or II. Patients scheduled for elective surgery under general anesthesia with orotracheal intubation

Exclusion criteria

• patient's refusal to join, major surgery or expected operation duration longer than 3 hours, patients with a anticipated difficult airway, requiring a nasogastric tube in peri-operative stage, having recent upper respiratory tract infection (within 1 week) or pre-existing sore throat.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: Quadruple Blind

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70 participants in 2 patient groups, including a placebo group

Lidocaine

Active Comparator group

Description:

Inhalation of lidocaine before intubation

Treatment:

Drug: Lidocaine inhalation

Control

Placebo Comparator group

Description:

Normal saline inhalation before intubation

Treatment:

Drug: Placebo