Inhalatorial Sedation in Patient With Subarachnoid Hemorrhage (SAH) Versus Conventional Intravenous Sedation (GAS-SAH)

Azienda Ospedaliera San Gerardo di Monza

Status and phase: Completed; Phase 4

Conditions: Subarachnoid Hemorrhage; Stroke

Treatments: Drug: Isoflurane; Drug: Propofol

Study type: Interventional

Funder types: Other

Identifiers

NCT00830843

1-citerio

Details and patient eligibility

About

Recent study has shown that inhalatory sedation is a practicable, effective and not risky method in Intensive Care Unit. Sevoflurane effect on cerebral system have been described in previous studies: it causes an increasing of cerebral blood flow and a decrease of oxygen cerebral consumption. Clinical strategy for Subarachnoid Hemorrhage is orientated to increase cerebral blood flow to limit vasospasm phenomena after SAH. Scope of this study is to evaluate the Cerebral Blood Flow variation associated to Isoflurane sedation versus conventional sedation with propofol .

Enrollment: 13 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• diagnosis of aSAH
• indication to DVE positioning
• clinical indication to sedation and assisted ventilation
• indication to ICP and CBF monitoring
• age > 18

Exclusion criteria

• documented cranial hypertension (ICP>18) not controller by liquor drainage
• age < 18.

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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13 participants in 2 patient groups

Propofol

Active Comparator group

Description:

Propofol(3-4 mg/kg/ora)administrated for 2 hours.

Treatment:

Drug: Propofol

Isoflurane

Experimental group

Description:

Isoflurane inhalatorial administration for 2 hours at 0.8-1.0% Minimum Alveolar Concentration

Treatment:

Drug: Isoflurane