Inhaled IAV vs Inhaled Eucalyptus for the Treatment of Nausea With Acute Migraine

HonorHealth Research Institute

Status: Active, not recruiting

Conditions: Migraine

Treatments: Other: Eucalyptus Oil Scent; Other: Isopropyl Alcohol Vapors

Study type: Interventional

Funder types: Other

Identifiers

NCT05175521

1718502

Details and patient eligibility

About

The goal of this study is to compare the efficacy and adverse events of inhaled isopropyl alcohol vapor (IAV) versus placebo (inhaled eucalyptus scent (IES) (1:20 dilution in mineral oil) for treating nausea associated with acute migraine attacks.

Full description

The main goal of this study is to examine the efficacy of (nausea reduction and time to use of other anti-nausea medications) and side effects of inhaled isopropyl alcohol vapor (IAV) for treating nausea among migraine patients using a double blind randomized control methodology. IAV is being compared inhaled eucalyptus scent (IES) (1:20 dilution in mineral oil) which has not shown benefit for treating nausea or migraine and is therefore considered placebo in this study.

Enrollment: 50 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients 18 to 65 years old with nausea associated migraines at least twice per month

Exclusion criteria

• Patients <18 or >65 years old
• Patients without a diagnosis of acute migraine

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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50 participants in 2 patient groups, including a placebo group

Eucalyptus Oil Scent

Placebo Comparator group

Description:

Eucalyptus oil diluted in mineral oil 1:20

Treatment:

Other: Eucalyptus Oil Scent

Isopropyl Alcohol Vapors

Active Comparator group

Description:

Isopropyl Alcohol 70%

Treatment:

Other: Isopropyl Alcohol Vapors