Inheritance of Osteosarcoma & Paget's Disease Through Chromosome 18:

State University of New York - Upstate Medical University

Status: Terminated

Conditions: Osteosarcoma; Paget's Disease

Study type: Observational

Funder types: Other

Identifiers

NCT00615628

Osteosarcoma & Paget's Disease

IRB #4168 (Other Identifier)

Details and patient eligibility

About

Researchers have previously demonstrated loss of heterozygosity in a region on chromosome 18q, associated with osteogenic sarcomas in bone affected by Paget's disease. The loci used in this study are specifically described by those authors as showing loss of heterozygosity in 6 of 7 affected families.

Full description

As above, no additional information

Enrollment: 8 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• This is a familial study therefore the only inclusion/exclusion criteria would be that subjects must be a blood relative and over the age of 18.
• The subjects are proband and father along with unaffected blood relatives. Their peripheral blood will act as a control and provide information to delineate the inheritance from the father, as seen in the son.

Exclusion criteria

• Not part of the family

Trial design

8 participants in 1 patient group

family members

Description:

family members of the proband and father identified