Inherited Susceptible Genes Among Epithelial Ovarian Cancer

Chinese Academy of Medical Sciences & Peking Union Medical College

Status: Unknown

Conditions: Hereditary Breast and Ovarian Cancer Syndrome; Ovarian Neoplasm Epithelial

Study type: Observational

Funder types: Other

Identifiers

NCT03015376

EOC-GENE

Details and patient eligibility

About

Purpose: To investigate the prevalence of the germline mutations in the BRCA 1/2 and mismatch repair genes in patients with epithelial ovarian cancer (EOC) and their relatives, and related somatic mutations in tumor tissues in the northern part of china.

Patients and methods: A multicenter prospective study will be hold in the northern part of china form 2017. About 1000 female patients with epithelial ovarian cancer and their ralatives will be tested for germline mutations in the BRCA 1/2 and mismatch repair genes and related somatic mutations in tumor tissues, regardless of the family history.

Study type: Observational Official title: Prevalence study of germline mutations in susceptibility ovarian cancer genes in patients with epithelial ovarian cancer and somatic mutations in their tumor tissures in the northern part of china.

Enrollment: 1000

Enrollment: 1,000 estimated patients

Sex: All

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. epithelial ovarian cancer and their relatves
2. living in the north of Huaihe River in China
3. being Han Chinese

Exclusion criteria

1. non-epithelial ovarian cancer
2. without specific pathological diagnosis
3. non-Han Chinese