Inhibition of Non-histaminergic Pruritus Applied Using 3 Different Pruritogens

Aalborg University

Status

Completed

Conditions

Itch

Treatments

Other: Vehicle cream for 1 hour

Drug: Emla 1 hour

Drug: EMLA 3 hours

Other: Cowhage

Other: Vehicle cream for 3 hours

Study type

Interventional

Funder types

Other

Identifiers

NCT04858360

N-20200073 1st sub-project

Details and patient eligibility

About

With this experiment, we want to use to investigate whether repeated application of EMLA cream as a tool to modulate non-histaminergic itching, which is produced using small needles from the plant mucuna pruriens (it is known that antihistamine does not attenuate this form of itch) and we want to compare the effect of short (1 hour) and prolonged (3 hours) application of EMLA. The sub-project takes place in 3 sessions over a period of 3 consecutive days (24 hours apart). All sessions will be identical.

Enrollment

22 patients

Sex

All

Ages

18 to 60 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Healthy men and women
18-60 years
Speak and understand English

Exclusion criteria

Pregnancy or lactation
Drug addiction defined as any use of cannabis, opioids or other drugs
Previous or current neurologic, musculoskeletal or mental illnesses that may affect the results (e.g. neuropathy, muscular pain in the upper extremities, etc.).
Lack of ability to cooperate
Current use of medications that may affect the trial such as antihistamine medications or pain killers.
Skin diseases
Hypersensitivity to papaya and mango fruit, cashew nuts and rubber latex
Consumption of alcohol or painkillers 24 hours before the study days and between these
Acute or chronic pain
Participation in other trials within 1 week of study entry (4 weeks in the case of pharmaceutical trials)
Known history of anaphylactic shock, or local allergy (contact dermatitis) to lidocaine, prilocaine or other local anaesthetics of the amide type.