Inhibitory Control and Eating Disorders (InhibEating)

Civil Hospices of Lyon

Status: Completed

Conditions: Bulimia Nervosa; Binge Eating; Anorexia Nervosa

Treatments: Other: Neuropsychological assessment : Go No Go task; Other: Neuropsychological assessment : Stroop task

Study type: Observational

Funder types: Other

Identifiers

NCT03850288

69HCL18_0621

Details and patient eligibility

About

Executive functions are part of the high-level cognitive processes essential to the proper functioning of human cognition. They consist mainly of flexibility, updating and inhibition. Some studies have shown a correlation between executive disorders (impaired executive function) and psychiatric disorders such as obsessive-compulsive disorder or phobias. These executive disorders are related to dysfunctions of the fronto-striatal loops.

In addition, other studies have investigated the link that may exist between eating disorders such as anorexia or bulimia nervosa and executive functioning. Anorexia nervosa, bulimia nervosa and binge eating disorders are eating disorders characterized by a dysfunction in food intake with restriction of food or compulsions as well as strong concerns about the body schema. Concerning the executive functioning, these studies highlight a lack of cognitive flexibility for patients with anorexia nervosa and bulimia nervosa but also dysfunctions depending on the type of pathology (anorexia nervosa or bulimia nervosa). These studies also highlight the beneficial effects of cognitive remediation on people with eating disorders.

However, the investigation of the inhibitory control has not yet been specifically studied. Moreover, since eating disorders are structurally different, a comparison between several pathologies would be interesting to consider.

The aim of this study is to determine if a dysfunction of inhibitory control can be highlighted in people with eating disorders. This study would also allow further researches about cognitive remediation suitable for the specific difficulties encountered in these diseases.

Enrollment: 17 patients

Sex: Female

Ages: 19 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Woman aged 19 to 40 years old
• Patient with a BMI between 13 and 40 kg/m2
• Outpatients of the Refering Center of Eating Disorders ('Hospices Civils de Lyon' in Lyon) suffering of an eating disorder diagnosis (Anorexia Nervosa, Bulimia Nervosa or Binge Eating Disorder)
• Patient who agrees to participate to the study.

Exclusion criteria

• Patient with psychiatric comorbidity severe (DSM V) and not stable (during the 8 weeks before inclusion)
• Patient with psychotropic treatment (started or modified during the 8 weeks before inclusion)
• Major patient protected by a measure of legal protection
• Patient younger than 19 years old
• Participation to another study at the same time

Trial design

17 participants in 3 patient groups

Anorexia Nervosa

Description:

Patients with a diagnosis of anorexia nervosa (According to the DSM-V criteria). These patients are characterized by a restriction of food intake leading to weight loss or a failure to gain weight resulting in a "significantly low body weight" of what would be expected for someone's age, sex and height. Moreover, there is a fear of becoming fat or of gaining weight.Then, these patients have a distorted view of themselves and of their condition.

Treatment:

Other: Neuropsychological assessment : Go No Go task

Other: Neuropsychological assessment : Stroop task

Bulimia Nervosa

Description:

Patients with a diagnosis of bulimia nervosa. According to the DSM-V criteria, these patients are characterized by recurrent episodes of binge eating (eating, in a discrete period of time, an amount of food that is definitely larger than most people would eat during a similar period of time and under similar circumstances), a sense of lack of control over eating during the episode, recurrent inappropriate compensatory behaviour in order to prevent weight gain, such as self-induced vomiting, misuse of laxatives, diuretics, or other medications, fasting, or excessive exercise. The binge eating and inappropriate compensatory behaviours both occur, on average, at least once a week for three months. Moreover, there is a self-evaluation influenced by body shape and weight.

Treatment:

Other: Neuropsychological assessment : Go No Go task

Other: Neuropsychological assessment : Stroop task

Binge Eating Disorder

Description:

Patients with a diagnosis of Binge Eating Disorder. These patients are characterized by recurrent episodes of binge eating (eating, in a discrete period of time (e.g. within any 2-hour period), an amount of food that is definitely larger than most people would eat during a similar period of time and under similar circumstances), a sense of lack of control over eating during the episode. The binge eating episodes are associated with three or more of the following: eating much more rapidly than normal, eating until feeling uncomfortably full, eating large amounts of food when not feeling physically hungry, eating alone because of feeling embarrassed by how much one is eating, feeling disgusted with oneself, depressed or very guilty afterward,marked distress regarding binge eating is present. Moreover, binge eating occurs, on average, at least once a week for three months

Treatment:

Other: Neuropsychological assessment : Go No Go task

Other: Neuropsychological assessment : Stroop task