Inhibitory Control: Effects of Modulation

Butler Hospital

Status: Enrolling

Conditions: Young Adults

Treatments: Device: Transcranial direct current stimulation

Study type: Interventional

Funder types: Other

Identifiers

NCT04247334

1352651-9

Details and patient eligibility

About

Inhibitory control is relevant to many clinical disorders, including substance abuse/dependence, obsessive-compulsive disorder, and attention-deficit hyperactivity disorder. This proposal is designed to assess brain networks related to response inhibition in healthy young adults, and use neuromodulation to change these networks and behavioral performance on a response inhibition task. Having an understanding of the brain mechanisms involved in response inhibition may enable us to improve pre-existing treatments for disorders with inhibitory control difficulties.

Enrollment: 108 estimated patients

Sex: All

Ages: 18 to 25 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Low (<1sd below the mean on the BRIEF-Inhibit) or high (>1sd above the mean on BRIEF-Inhibit scale)
2. English fluency to ensure comprehension of study measures and instructions.

Exclusion criteria

1. Presence of medical conditions contraindicated for tDCS, including history of any known intracranial pathology, epilepsy or seizures, traumatic brain injury, brain tumor, stroke, implanted medical devices, current pregnancy or women of childbearing age not using effective contraception, or any other serious medical conditions or health problems that would interfere with participation (e.g., skin condition)
2. Inability to undergo MRI
3. Current substance abuse disorder
4. Currently prescribed psychiatric medications.
5. Active mania or psychosis

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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108 participants in 3 patient groups

Cautious Participants

No Intervention group

Description:

Participants who have low scores on a self-report of inhibitory control abilities (BRIEF-Inhibit).

Impulsive Participants- Active Stimulation

Experimental group

Description:

Participants who have high scores on a self-report of inhibitory control abilities (BRIEF-Inhibit) who are randomized to active stimulation.

Treatment:

Device: Transcranial direct current stimulation

Impulsive Participants- Sham Stimulation

Sham Comparator group

Description:

Participants who have high scores on a self-report of inhibitory control abilities (BRIEF-Inhibit) who are randomized to sham stimulation.

Treatment:

Device: Transcranial direct current stimulation