Initial Clinical and CBCT Outcomes of Enamel Matrix Derivative-Based Regenerative Therapy in Vertical Bone Defects

Tsvetalina Gerova-Vatsova

Status: Completed

Conditions: Vertical Alveolar Bone Loss

Treatments: Procedure: Guided Tissue Regeneration (barrier membrane); Procedure: EMD (Enamel Matrix Derivative); Procedure: Guided Tissue Regeneration(barrier membrane and PRP); Procedure: PRP( platelet rich plasma)

Study type: Interventional

Funder types: Other

Identifiers

NCT06639555

118/23.06.22

Details and patient eligibility

About

Study of the effectiveness of the application of regenerative therapy with autogenous, platelet-rich plasma in vertical defects Investigation of the effectiveness of the application of regenerative therapy with enamel matrix derivatives in vertical bone defects Study of the effectiveness of the application of guided tissue regeneration in vertical bone defects with Barrier membrane and Barrier membrane and autogenous platelet-rich plasma

Enrollment: 48 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• good oral hygiene
• written informed consent
• age
• no systemic diseases

Exclusion criteria

• smokers
• horizontal bone loss
• untreated periodontium disease

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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48 participants in 4 patient groups

PRP alone

Active Comparator group

Treatment:

Procedure: PRP( platelet rich plasma)

EMD Alone

Active Comparator group

Treatment:

Procedure: EMD (Enamel Matrix Derivative)

GTR (barrier membrane)

Active Comparator group

Treatment:

Procedure: Guided Tissue Regeneration (barrier membrane)

GTR(barrier membrane and PRP)

Active Comparator group

Treatment:

Procedure: Guided Tissue Regeneration(barrier membrane and PRP)