Injectable Platelet-rich Fibrin and Advanced Platelet-rich Fibrin With Xenograft on the Socket Preservation of Mandibular Extracted Molars

Hams Hamed Abdelrahman

Status: Completed

Conditions: Tooth Extraction; Socket Preservation

Treatments: Other: I-PRF; Other: Control; Other: A-PRF

Study type: Interventional

Funder types: Other

Identifiers

NCT06936358

0663_04/2023

Details and patient eligibility

About

Different materials and techniques are employed for socket preservation to reduce the alveolar bone resorption in both the horizontal and vertical dimensions as well as the soft tissue collapse after tooth extraction. Because of the repair abilities of the growth factors and proteins released by platelets, the development and application of platelet-enriched preparations have revolutionised the area of regenerative medicine.The present study will be designed to study the difference between A-PRF and IPRF with the addition of Xenograft in the preservation of bone in mandibular molars.

Enrollment: 16 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients who need extraction of hopeless mandibular molars
• Teeth with advanced caries not amenable for conservative treatment
• Patients who are willing and fully capable of complying with the study protocol.

Exclusion criteria

• Systemic diseases that prevent surgery
• Acute or chronic oral infections
• Periodontal diseases
• Heavy smokers or alcoholics
• On anticoagulant drugs.
• Pregnancy
• History of radiotherapy or chemotherapy of the head and neck region

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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16 participants in 3 patient groups

Control

Active Comparator group

Treatment:

Other: Control

A-PRF

Experimental group

Treatment:

Other: A-PRF

I-PRF

Experimental group

Treatment:

Other: I-PRF