Injectable Platelet Rich Fibrin Versus Platelet Rich Plasma Injection in Degenerative Temporomandibular Joint

Nasser Institute For Research and Treatment

Status: Completed

Conditions: Platelet Rich Fibrin; Platelet Rich Plasma Injection; Degenerative Temporomandibular Joint

Treatments: Other: Platelet Rich Plasma; Other: Platelet Rich Fibrin

Study type: Interventional

Funder types: Other

Identifiers

NCT07078006

55653465

Details and patient eligibility

About

The study aimed to compare the efficacy of injectable platelet rich fibrin (I-PRF) versus platelet rich plasma (PRP) injection in degenerative temporomandibular joint (TMJ).

Full description

Degenerative joint disease (DJD), a frequently observed as osteoarthritic condition in clinical practice, manifests as a persistent and continuous transformation in joint configuration due to the deterioration and attrition of articular cartilage, accompanied by modifications in the subchondral bone and other soft tissue.

Treatment includes physical therapy, pulsed electrical stimulation, pharmacological, topical ointments, supplements, steroid injections, hyaluronic acid (HA) injections, and acupuncture.

Further studies have been carried out to better investigate the effectiveness of different techniques to perform arthrocentesis by using growth factors, autologous solutions, or alternative materials; the materials most used are platelet-rich plasma (PRP) and HA in arthrocentesis or by injection.

Enrollment: 20 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age >18 years old.
• Both sexes.
• Patients with unilateral or bilateral temporomandibular joint (TMJ) osteoarthritis according to magnetic resonance imaging (MRI) evaluation.

Exclusion criteria

• Patients under any type of antiplatelet or anticoagulant medications.
• Cardiovascular, renal, or hepatic disease.
• Diabetes.
• Anemia.
• Vascular insufficiency.
• Peripheral neuropathy.
• Previous surgery for TMJ and rheumatoid arthritis.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Sequential Assignment

Masking: None (Open label)

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20 participants in 2 patient groups

Group I

Experimental group

Description:

Patients underwent arthrocentesis followed by a platelet-rich fibrin (PRF) injection using a conventional temporomandibular joint (TMJ) injection technique, aided by facial anatomical landmarks.

Treatment:

Other: Platelet Rich Fibrin

Group II

Active Comparator group

Description:

Patients underwent arthrocentesis followed by a platelet-rich plasma (PRP) injection using a conventional temporomandibular joint (TMJ) injection technique, aided by facial anatomical landmarks.

Treatment:

Other: Platelet Rich Plasma