Injectable Platelet Rich Fibrin With Collagen Matrix in Treatment of Multiple Gingival Recession.

University of Baghdad

Status: Unknown

Conditions: Gingival Diseases; Traumatic Injury

Treatments: Procedure: I-PRF; Procedure: CAF+CM

Study type: Interventional

Funder types: Other

Identifiers

NCT05389059

519622

Details and patient eligibility

About

This study is proposing the use of i-PRF clot as a scaffold for the XCM in order to obtain a novel biomaterial, incorporating active growth factors and collagen matrix in a single framework, based on the potential effect of i-PRF to enhance fibroblast activity and angiogenesis stimulation for treatment of multiple gingival recession.

Enrollment: 20 estimated patients

Sex: All

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Presence of at least two localized gingival recessions on either sides of the maxilla and/or mandible excluding molar region.
• The cemento-enamel junction (CEJ) is visible in the teeth for root coverage procedures.
• All recessions are type 1recession RT1 (cairo et al,2011) which correspond to Miller I&II gingival recession
• All patients must demonstrate adequate plaque control with a fullmouth plaque score less than 20% and with .
• All patients at least 18 years of age and of both genders.

Exclusion criteria

• Smoker Patients .
• Patients with diabetes.
• Patients with a history of malignancy, radiotherapy, or chemotherapy for malignancy.
• pregnant or nursing women.
• Patients taking medications or having treatments with an effect on mucosal healing in general (e.g. steroids, large doses of antiinflammatory drugs).
• Patients with a disease affecting connective tissue metabolism.
• Patients allergic to collagen.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

---

20 participants in 2 patient groups

Control arm

Other group

Description:

Patients with Gingival recessions are type 1 recession RT1 (cairo et al,2011) which correspond to Miller I\&II gingival recession.

Treatment:

Procedure: CAF+CM

Experimental arm

Other group

Description:

Patients with Gingival recessions are type 1 recession RT1 (cairo et al,2011) which correspond to Miller I\&II gingival recession.

Treatment:

Procedure: I-PRF

Procedure: CAF+CM