Injectable PRF in Non-Surgical Periodontal Treatment (IPRF-PERIO)

Al-Mustansiriyah University

Status: Active, not recruiting

Conditions: Periodontitis; Periodontal Pocket; Alveolar Bone Loss

Treatments: Biological: Injectable Platelet-Rich Fibrin (i-PRF).; Procedure: Scaling and Root Planing (SRP).

Study type: Interventional

Funder types: Other

Identifiers

NCT07375004

UOM-DENT-ETHIC-2026-042

Details and patient eligibility

About

This study aims to evaluate the clinical and microbiological effects of using injectable Platelet-Rich Fibrin (i-PRF) as an adjunct to non-surgical periodontal therapy (scaling and root planing) in patients with periodontitis. The study uses a split-mouth design where one side of the mouth receives the treatment with i-PRF and the other side receives standard treatment alone. Clinical parameters and bacterial counts will be compared at baseline, 1 month, and 3 months after intervention .

Full description

Patients with periodontitis will be recruited for this split-mouth randomized controlled trial. All participants will receive full-mouth supra and sub-gingival scaling and root planing (SRP). In the intervention side, i-PRF will be injected into the periodontal pockets, while the control side will receive SRP only.

Clinical measurements including Probing Pocket Depth (PPD), Clinical Attachment Level (CAL), and Bleeding on Probing (BOP) will be recorded. Additionally, microbiological samples will be collected to assess the changes in the subgingival Porphyromonas gingivalis and Fusobacterium nucleatum . Follow-up visits are scheduled at 1 and 3 months post-intervention to assess the adjunctive benefit of i-PRF.

Enrollment: 13 patients

Sex: All

Ages: 30+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult subjects aged 30 years and above.
• No history of systemic diseases (e.g., diabetes mellitus).
• Not currently under active periodontal therapy or joining other trial in the last 3 months.
• Diagnosis with Stage II or III Periodontitis.
• presence of interdental CAL affecting ≥2 non adjacent teeth or if CAL at buccal/lingual aspects associated with PPD >4mm at ≥2 teeth.

Exclusion criteria

• Smokers or alcohol users.
• Patients consuming antibiotics or anticoagulants.
• Regular users of non-steroidal anti-inflammatory drugs.
• Receipt of periodontal treatment within 3 months prior to the study.
• Any bleeding or clotting disorders.
• Teeth with Grade II or Grade III furcation involvement.
• Pregnant or breastfeeding mothers.
• Patients unwilling to participate.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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13 participants in 2 patient groups

Experimental: i-PRF + SRP

Experimental group

Description:

This quadrant of the mouth will receive full-mouth scaling and root planing (SRP) followed by the subgingival injection of injectable Platelet-Rich Fibrin (i-PRF) into the periodontal pockets

Treatment:

Procedure: Scaling and Root Planing (SRP).

Biological: Injectable Platelet-Rich Fibrin (i-PRF).

Active Comparator: SRP Alone

Active Comparator group

Description:

This contralateral quadrant of the mouth will receive full-mouth scaling and root planing (SRP) only, serving as the control side to compare with the i-PRF intervention.

Treatment:

Procedure: Scaling and Root Planing (SRP).