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Innovative Brain Stimulation for Induction of Learning Plasticity

U

University of Geneva, Switzerland

Status

Unknown

Conditions

Healthy

Treatments

Device: rTMS device

Study type

Interventional

Funder types

Other

Identifiers

NCT04140994
Project-ID 2019-01440 CCER

Details and patient eligibility

About

Recent studies have identified new neurobiological biomarker (i.e. functional connectivity of the parietal cortex) of motor learning among healthy people. This enables to refine our current model of motor learning wherein specific cortical processes are key factors for motor acquisition. Furthermore, recent evidence suggests that new technical approaches such as repetitive magnetic stimulation (rTMS) can efficiently influence this key factor. However, up to now, no rTMS studies have target this new biomarker. Therefore, the effect of rTMS are unknown. Hence, the investigators want to develop a new rTMS setup able to induce specific brain processes in healthy individuals that are likely to benefit. This has the potential to obtain critical information in order to improve treatment of motor re-learning in patients with neurological diseases.

Full description

Participants will participate in 1 session of neuronavigated (TMS Navigator, Localite, Schloss Birlinghoven, D-53757, Sankt Augustin, Germany ) iTBS (patterned form of rTMS) coupled with motor learning. Participants will be randomly assigned to one of 2 groups: real iTBS over parietal cortex and sham iTBS over the parietal cortex.

One day before (Day1) and after the motor learning (Day 2), participants will undergo high-density 128-channel resting state electroencephalography (EEG) and motor evoked potential (MEP) in order to characterize the effects of rTMS on our markers of plasticity. Performance on the task will be measure immediately after learning (Day 2) and again 24h later (Day 3) in order to test for retention and offline consolidation (time and errors). The task will consist in realizing a computerized mirror-drawing task, in which right-left movements of the mouse were reversed on the screen.

Enrollment

40 estimated patients

Sex

All

Ages

18 to 40 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • man or woman aged between 18-40 years,
  • ability to give informed consent,
  • ability to follow protocol instructions,
  • normal or corrected-to-normal vision,

Exclusion criteria

  • history of epileptic seizure (ci. TMS),
  • skull breach (ci. TMS),
  • metallic object in the brain (ci. TMS),
  • pacemaker (ci. TMS),
  • severe co-morbidity (ex, traumatic, rheumatologic, neurodegenerative diseases),
  • pregnancy.

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Double Blind

40 participants in 2 patient groups

Intermittent theta burst stimulation
Active Comparator group
Description:
Volunteers will be submitted to non-invasive parietal stimulation before a mirror drawing task. A transcranial magnetic stimulator (MagPro X100, Medtronic Functional Diagnostics, Skovlunde, Denmark) will deliver interrmittent bursts of bipolar magnetic pulses exerting an excitation on the underlying brain tissue (iTBS). The stimulation coil will be placed over the parietal cortex. Stimulation consisted of a burst of three pulses administered at 50Hz, repeated at a frequency of 5Hz, delivered in 2 s trains followed by an 8 s interval for a total of 600 pulses12. Stimulation intensity was set at 70% of RMT. Each session will consist of two spaced neuronavigated iTBS applications, separated by 15 minutes.
Treatment:
Device: rTMS device
Sham intermittent theta burst stimulation
Sham Comparator group
Description:
For sham iTBS, the protocol is the same, except the sham coil produces no magnetic field.
Treatment:
Device: rTMS device

Trial contacts and locations

1

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Central trial contact

Pierre Nicolo, PhD; Pierre Nicolo, PhD

Data sourced from clinicaltrials.gov

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