Inosine Energy Expenditure Study (InoBAT)

University Hospital Basel

Status: Completed

Conditions: Healthy Volunteers

Treatments: Other: Placebo; Dietary Supplement: Inosine

Study type: Interventional

Funder types: Other

Identifiers

NCT04476238

2020-01026

Details and patient eligibility

About

Investigators want to test whether the intake of the nucleoside inosine increases the human energy expenditure. Inosine occurs as a metabolic intermediate in the human body and is sometimes taken as a dietary supplement by athletes.

For this purpose, investigators will measure the basal metabolic rate by indirect calorimetry. Study participants will then take inosine dissolved in water or placebo and energy expenditure will be assessed again.

Enrollment: 8 patients

Sex: Male

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy male volunteers
• BMI between 18-27 kg/m2
• Age between 18 and 40 years

Exclusion criteria

• Chronic concomitant disease states (e.g., renal failure, hepatic dysfunction, cardiovascular disease, diabetes mellitus),
• Known or suspected non-compliance, drug or alcohol abuse,
• Inability to follow the procedures of the study
• Participation in another study with investigational drug within the 30 days preceding and during the present study,
• Previous enrolment into the current study,
• Enrolment of the investigator, his/her family members, employees and other dependent persons,
• Thyroid disorders

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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8 participants in 2 patient groups, including a placebo group

Inosine

Experimental group

Description:

2 grams of inosine dissolved in 250 ml of tap water

Treatment:

Dietary Supplement: Inosine

Water

Placebo Comparator group

Description:

250 ml of tap water only

Treatment:

Other: Placebo