Inpatient Package to Reduce HIV and AIDS-related Death in Zambia (IPADZ)

The University of Alabama at Birmingham

Status: Completed

Conditions: Tuberculosis; Hospitalization; Cryptococcosis; Transitions of Care; HIV Testing; HIV/AIDS

Treatments: Diagnostic Test: Inpatient lab bundling; Behavioral: Inpatient navigation

Study type: Interventional

Funder types: Other

Identifiers

NCT04033718

300003461

Details and patient eligibility

About

Early post-discharge mortality is high among HIV-infected Zambians admitted to the hospital. Likely this is in part due to missed opportunities to identify lethal coinfections and optimize HIV care during admission (and before discharge). In this study the investigators will develop and pilot a new approach to inpatient HIV care that follows international guidelines for management of advanced HIV disease.

Enrollment: 72 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 18+ years old
• HIV-positive (by self-report or DCT result in UTH file)
• Resident of Lusaka
• Admitted to the hospital

Exclusion criteria

• Too sick to provide informed consent (based on clinician opinion)
• Likely to be discharged in the next 48 hours (based on clinician opinion)

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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72 participants in 2 patient groups

Inpatient lab bundling plus navigation

Experimental group

Description:

Testing for CD4 count, tuberculosis, cryptococcus, and HIV RNA with samples collected in a bundle-type approach. Additional inpatient support from a patient navigator

Treatment:

Behavioral: Inpatient navigation

Diagnostic Test: Inpatient lab bundling

Inpatient lab bundling alone

Experimental group

Description:

Testing for CD4 count, tuberculosis, cryptococcus, and HIV RNA with samples collected in a bundle-type approach.

Treatment:

Diagnostic Test: Inpatient lab bundling