Insecticide Resistance Management in Burkina Faso and Côte D'Ivoire (REACT)

French Public Scientific and Technological Institution (EPST)

Status and phase: Completed; Phase 3

Conditions: Malaria

Treatments: Biological: Ivermectin; Behavioral: BCC; Device: Larvicide; Device: Indoor residual sprayings

Study type: Interventional

Funder types: Other

Identifiers

NCT03074435

InstitutRD

15SANIN213 (Other Grant/Funding Number)

Details and patient eligibility

About

This study evaluates the benefit to use 1) insecticide residual sprayings, 2) larvicides, 3) Ivermectin for domestic animals and 4) behaviour change communication strategy to complement the universal coverage with LLINs through a cluster randomized trial.

Enrollment: 15,776 patients

Sex: All

Ages: 6 months to 21 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

For Cross-sectional surveys only, maximum age for participating in the study was 21 y/o in Côte d Ivoire and 18 y/o in Burkina Faso.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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15,776 participants in 5 patient groups

Control arm (LLIN-alone)

No Intervention group

Description:

The baseline and control intervention (LLIN-alone) correspond to what is implemented in each country by their respective National Malaria Control Programs (NMCP). This include universal coverage with Long-Lasting insecticidal Nets (LLIN). This arm is common to both countries (Burkina Faso and Côte d'Ivoire)

LLIN + indoor residual sprayings

Experimental group

Description:

LLIN+IRS arm consisted in applying, in addition to LLINs, IRS with Actellic® 300CS (Syngenta AG, Basel, Switzerland) at a target dosage of 1 g. of active ingredient (pirimiphos-methyl) per m² in every houses of the selected villages. This arm is common to both countries (Burkina Faso and Côte d'Ivoire)

Treatment:

Device: Indoor residual sprayings

LLIN + Larvicide

Experimental group

Description:

The intervention consists in treating Anopheles breeding sites with BTI biological larvicide, in addition to LLINs. This arm was implemented in Côte d'Ivoire only.

Treatment:

Device: Larvicide

LLIN+ One-health Ivermectin

Experimental group

Description:

This arm consists in monthly injections of ivermectin to peri-domestic farm animals (mammals) during 4 consecutive months, oin addition to LLINs. This arm was implemented in Burkina Faso only.

Treatment:

Biological: Ivermectin

LLIN + Behaviour Change Communication

Experimental group

Description:

BCC complementary intervention (LLIN+BCC arm) was designed to target the following behaviors in the human population: (i) everyone sleep under an LLIN every night, (ii) every household and community member cleans up its environment to limits mosquito proliferation, (iii) every pregnant woman asks for, and takes the intermittent preventive treatment of malaria during pregnancy (ITP) and, (iv) people in charge of \<5 y/o children come to see an health worker within 24h in case of fever. The intervention involve one health worker from the community per 35 households. Every health worker has the objective to perform 15 home visits (15-20 min), 20 interpersonal talks (15-20 min) and 4 group talks (15-30 min) per months.

Treatment:

Behavioral: BCC