Inside a Neuron - Ex Vivo Evaluation of Cerebral and Cerebellar Neuronal Activity. (INSANE)

Institute of Hospitalization and Scientific Care (IRCCS)

Status: Enrolling

Conditions: Human Neural Cells Functioning

Study type: Observational

Funder types: Other

Identifiers

NCT06896331

INSANE

Details and patient eligibility

About

Understanding the functioning of human neurons has always been a key element, especially with regard to the translation of the inputs they receive into actions that determine human behavior. However, the vast majority of studies have been performed in animal models due to the difficulty in maintaining neuronal functions ex vivo. Recently, techniques have been illustrated that allow us to obtain slices of brain tissue removed during neurosurgical interventions. The patch-clamp and HD-MEA (high density - microelectrodes array) techniques, used until now for animal samples, can allow us to study the functioning of the neural cells that make up these slices. Furthermore, the exploration of the functioning of the aforementioned cells in pathological conditions can open the field for further therapeutic perspectives.

Enrollment: 60 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients with a brain/cerebellum primary or secondary tumor for whom at least partial resection has been planned.

Exclusion criteria

• patients with a brain/cerebellum primary or secondary tumor for whom a biopsy has been planned

Trial design

60 participants in 1 patient group

Study group

Description:

Patients subdued to neurosurgical intervention for the removal of brain or cerebellum primary or secondary tumor