Inspiratory Muscle Training and Asthma

University of Portsmouth

Status: Completed

Conditions: Asthma

Treatments: Other: inspiratory muscle training

Study type: Interventional

Funder types: Other

Identifiers

NCT01727765

IMT and Asthma

Details and patient eligibility

About

This is a pilot study which will assess the feasibility of a follow on main study. This study will examine the impact of inspiratory muscle training on quality of life, rescue drug medication usage, and other markers of asthma in adult asthmatics in the UK.

Enrollment: 16 patients

Sex: All

Ages: 18 to 59 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Asthma Control Questionnaire score of ≥ 1.5
• 10 mg or less of prednisolone (or equivalent) daily
• Aged 18 to 59 years inclusive
• Able to provide written informed consent

Exclusion criteria

• Any significant heart or lung disease other than asthma including any previous history of pneumothorax
• Patients with a concomitant condition (including clinically relevant cardiovascular, hepatic, neurological, endocrine, or other major systemic disease) not controlled with treatment, making implementation of the protocol or interpretation of the study results difficult
• Women who are pregnant
• Forced expiratory volume in one second of less than 50% best or predicted
• A history of smoking 20 cigarettes a day for 20 years or more (or an equivalent amount)
• Undertaken a structured program of inspiratory muscle training within the past three months
• Currently a participant in another interventional study

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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16 participants in 2 patient groups

Experimental

Experimental group

Description:

6 weeks of inspiratory muscle training, 6 days per week. The intensity of training will be equivalent to up to 50% of pre-training maximal inspiratory mouth pressure and will be adapted weekly to reflect the improvement in inspiratory muscle strength

Treatment:

Other: inspiratory muscle training

Sham Comparator

Sham Comparator group

Description:

6 weeks of sham inspiratory muscle training, 6 days per week. The intensity of training will be equivalent to 5% of pre-training inspiratory mouth pressure throughout the 6 week period.

Treatment:

Other: inspiratory muscle training