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Inspiratory Muscle Training in Pulmonary Arterial Hypertension

G

Golden Jubilee National Hospital

Status

Unknown

Conditions

Pulmonary Hypertension

Treatments

Device: Inspiratory muscle training device

Study type

Interventional

Funder types

Other

Identifiers

NCT04197388
18/CARD/31

Details and patient eligibility

About

Pulmonary arterial hypertension is a rare condition characterised by high blood pressure in the lungs and results in breathlessness and reduced exercise capacity for patients. Previous research has shown weakness in respiratory muscles in these patients that may contribute towards their symptoms. Despite advances in medical therapy, the condition still results in a significant symptom burden.

Inspiratory muscle training is a non-invasive intervention involving a device that provides resistance to the muscles of inspiration and increases their strength.

This study will investigate the benefit of inspiratory muscle training in patients with pulmonary arterial hypertension who are stable on medical therapy for three months. This will be performed as an outpatient and they will then be reviewed following this with assessment of exercise capacity, breathing capacity (spirometry), quality of life, and assessment of neural respiratory drive (the signals from the brain to the muscles controlling breathing).

The study will be based at the Golden Jubilee National Hospital and patients will be recruited from outpatients who are already under the care of the Scottish Pulmonary Vascular Unit.

Enrollment

20 estimated patients

Sex

All

Ages

18 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • diagnosed by pulmonary hypertension specialist with precapillary pulmonary hypertension
  • able to give consent
  • stable on medical therapy for at least 3 months

Exclusion criteria

  • significant contribution to pulmonary hypertension from lung disease
  • pregnant

Trial design

Primary purpose

Treatment

Allocation

N/A

Interventional model

Single Group Assignment

Masking

None (Open label)

Trial contacts and locations

1

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Central trial contact

Paul McCaughey

Data sourced from clinicaltrials.gov

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