INSTANT: INtegrilin Plus STenting to Avoid Myocardial Necrosis Trial

Fondazione Evidence per Attività e Ricerche Cardiovascolari ONLUS

Status and phase

Completed

Phase 3

Conditions

Cardiovascular Disease

Treatments

Drug: eptifibatide

Drug: placebo

Study type

Interventional

Funder types

Other

Identifiers

NCT00638976

Fondazione Mediolanum 001/2007

Details and patient eligibility

About

Randomized, blind controlled, Multicenter, spontaneous, prospective trial, roughly 20 enrolling centers in Italy, placebo and active drug supply given by GlaxoSmithKline (GSK).

Full description

The Objective of the trial is compare the efficacy and, secondarily, the safety and effectiveness of pre-procedural use of the Gp IIb/IIIa inhibitor eptifibatide in comparison to placebo in patients with diffuse CAD undergoing multiple DES implantation.

Enrollment

91 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Candidates for this study must meet all of the following criteria:

Male or female able to understand and sign a witnessed informed consent
Age ≥ 18 yo
Patients with stable (CCS 1-4) or unstable angina pectoris (but with the most recent anginal episode occurring >48 hours before the procedure) or documented silent ischemia
Stable Hemodynamic conditions (systolic BP > 100 HR > 40 < 100).
No clinical and ECG changes suggestive of ongoing acute or recent (<48 hours) myocardial infarction.
Angiographic evidence of a de novo lesion > 50% requiring implantation of two DES in overlapping with a total stent length > 33 mm and reference vessel diameter between 2.5 and 4.0 mm (by visual estimation) in one coronary vessel. Multiple lesions in the same vessels can be included but at least one lesion should require implantation of two DES in overlapping with a total stent length > 33 mm. The definition of multivessel disease requires an intention to treat at least two lesions (with a least one with the characteristics reported above) in two different major epicardial segments. For example, the presence of a lesion in the left anterior descending artery and in the obtuse marginal or the presence of a lesions in the right postero-lateral branch and in a diagonal branch will qualify as multivessel. The presence of lesions in the left anterior descending artery and in the diagonal branch will not qualify as multivessel. Bifurcation lesions and ostial lesions can be included, but only if at least two DES in overlapping with a total stent length > 33 mm are implanted in the same branch. When treating diffuse lesion in the same vessel, overlapping stenting is recommended with high pressure (>14 atm post-dilation) of the overlap zone. There is no maximum stent length to treat one coronary vessel.

Exclusion criteria

Female sex with childbearing potential
Age <18 years
Ongoing or recent episode (<48 hours) of unstable coronary artery disease (including both ST-elevation and non-ST-elevation acute coronary syndromes)
Administration of any GP IIb/IIIa inhibitors during the previous 2 weeks
Serum creatinine >2.5 mg/dl or with a creatinine clearance <40mL/min
Ongoing serious bleeding or bleeding diathesis
Previous stroke in the last 6 months
Major surgery within the previous 6 weeks
Platelet count <100,000 per mm3
Ejection Fraction below 30%
The patient has a known hypersensitivity or contraindication to aspirin, heparin, clopidogrel, or sensitivity to contrast which cannot be adequately pre-medicated.
Hemodynamic instability (systolic blood pressure < 100 mm Hg; heart rate < 40 bpm or >100 bpm; complex ventricular arrhythmias; AV block) requiring balloon counterpulsation or inotropic support.
The patient is simultaneously participating in another device or drug study. Patient must have completed the follow-up phase of any previous study at least 30 days prior to enrolment in this study.
Positive clinical history for intracranial neoplasia, AV malformation, aneurysm.
INR ≥ 2.0 or prothrombin time 1.2 times upper limit of normality
Clinically manifested reduced liver function
Programmed surgery within six months

Angiographic Exclusion Criteria:

DES implantation in a chronic total occlusion or for the treatment of in-stent restenosis.
Treatment of lesions where the operator feels necessary the usage of rotactional atherectomy
Vessel size < 2.25 mm or > 5 mm (by visual estimation).
Previous implantation of a bare/DES in the target lesion