Insulin and Muscle Fat Metabolism

Oregon State University (OSU)

Status: Terminated

Conditions: Mitochondrial Metabolism; Insulin Resistance; Overweight and Obesity; Sedentary Lifestyle; Metabolic Disease

Treatments: Other: Hyperinsulinemic-euglycemic Clamp

Study type: Interventional

Funder types: Other

Identifiers

NCT04759872

IRB-2020-0768

Details and patient eligibility

About

Our objective in this study is to identify the extent to which insulin drives the accumulation of lipids in skeletal muscle of humans. We will test the hypothesis that 4-hours of mild hyperinsulinemia will result in significant muscle lipid accumulation and that such effects will be similar in lean and overweight/obese humans.

Enrollment: 9 patients

Sex: All

Ages: 30 to 55 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age 30-55 years
• Body mass index (BMI) 18-45 kg/m2
• Sedentary (<1 hour of planned exercise per week)

Exclusion criteria

• Regular exercise (>1 hour of planned exercise per week)
• Smoking, tobacco or nicotine use within the last 1-year
• Fasting glucose >126mg/dL
• Hypertension (systolic pressure >140 mmHg or diastolic pressure >90 mmHg)
• Chronic metabolic or cardiovascular health conditions
• Pregnant, nursing, irregular menses or post-menopausal
• Lidocaine allergy
• Certain medications
• Diminished capacity for consent

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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9 participants in 1 patient group

Metabolic Study Visit

Experimental group

Description:

Participants will complete a study visit for metabolic phenotyping and determination of the impact of hyperinsulinemia on outcomes of interest.

Treatment:

Other: Hyperinsulinemic-euglycemic Clamp