Insulin Cardioplegia for Poor Left Ventricular Function

University Health Network, Toronto

Status

Unknown

Conditions

Left Ventricular Dysfunction

Treatments

Drug: Insulin Cardioplegia

Study type

Interventional

Funder types

Other

Identifiers

NCT00188994

CIHR Grant No. HSF NA4189

98-E089

Details and patient eligibility

About

The purpose of this investigation is to develop a means to improve the recovery of cardiac metabolism and ventricular function following coronary artery bypass surgery (CABG) in patients with poor preoperative ventricular function (e.g. ejection fraction <40%).

Full description

Hypothesis

Insulin added to blood cardioplegia will improve the results of Coronary Artery Bypass Graft by reducing the incidence of low output syndrome (i.e., the requirement for inotropic or balloon pump assistance) in patients with a preoperative ejection fraction <40%.

Sex

All

Volunteers

No Healthy Volunteers

Inclusion criteria

Patient has been referred for isolated coronary bypass surgery.
LV grade 3 or 4, LVEF <40% by angio, echo, RNA.

Exclusion criteria

Patient is undergoing reoperative surgery (i.e., has had any previous cardiac surgery)
Surgeon has planned another procedure in addition to coronary bypass surgery (e.g., valve repair, replacement, ascending aorta repair or replacement, left ventricular aneurysm resection, repair of congenital defect, carotid surgery, repair of abdominal aortic aneurysm).
Patient is scheduled for minimally invasive surgery.
More recent assessment of LV function with LV grade 1 0r 2, LVEF>40%.
5 or 6 days post MI.