Insulin Resistance and Hypertensive Disorders in Pregnancy

University of Messina

Status: Completed

Conditions: Diabetes Mellitus in Pregnancy; Hypertension in Pregnancy

Study type: Observational

Funder types: Other

Identifiers

NCT00412230

120254

Details and patient eligibility

About

The purpose of this study is to determine whether insulin resistance might affect the pathogenesis of hypertensive disorders in pregnancy since midtrimester. Furthermore, markers of vascular and placental injuries, of oxidative stress and inflammation will be evaluated.

Enrollment: 100 estimated patients

Sex: Female

Ages: 18 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• PCOS, BMI>/=30
• previous pregnancy affected by hypertension or gestational diabetes
• thrombophilia
• Type I or II diabetes mellitus
• autoimmune diseases
• twin pregnancy
• renal diseases
• previous pre-eclampsia in relatives

Trial design

100 participants in 2 patient groups

no treatment

2