Insulin Resistance in Idiopathic Oligospermia and Azoospermia

The Egyptian IVF-ET Center

Status: Completed

Conditions: Oligospermia; Azoospermia; Insulin Resistance

Treatments: Other: blood samples; Other: Blood samples

Study type: Interventional

Funder types: Other

Identifiers

NCT01509482

insulin resistance

Details and patient eligibility

About

Insulin resistance in men can be the underlying major factor in reproductive abnormalities ( chronic hypospermatogenesis ) as well as metabolic abnormalities similar to polycystic ovarian syndrome ( PCOS ) in women.

Full description

During the past decade IR has been recognized as a major contributor to the pathogenesis of chronic anovulation, hyperandrogenism and metabolic abnormalities associated with PCOS . Theoretically IR in men may result in a similar reproductive abnormalities ( chronic hypospermatogenesis ) as well as other metabolic abnormalities similar to what happens in PCOS in women .

Enrollment: 100 patients

Sex: Male

Ages: 25 to 55 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• sperm count less than 10 million per milliliter
• non-obstructive azoospermia

Exclusion criteria

• high FSH ( > 10 mIU/ ml )
• high prolactin ( > 36 mIU/ml )
• abnormal karyotype
• AZF

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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100 participants in 2 patient groups

insulin resistance

Experimental group

Description:

unexplained oligospermia and azoospermia. Blood samples will be taken for hormonal and blood lipids analysis.

Treatment:

Other: blood samples

Fertile males

Active Comparator group

Description:

Healthy Men with proven fertility. Blood samples will be taken for hormonal and blood lipids analysis

Treatment:

Other: Blood samples