Insulin Resistance in Primary Hyperparathyroidism (IRIPH)

Karolinska University Hospital

Status: Withdrawn

Conditions: Diabetes; Hypercalcemia; Hyperparathyroidism

Treatments: Procedure: parathyroidectomy

Study type: Interventional

Funder types: Other

Identifiers

NCT02711059

KarolinskaUH_pHPT_diabetes

Details and patient eligibility

About

The aims of this study is to analyse if insulin resistance in primary hyperparathyroidism (pHPT) is normalised after parathyroid adenomectomy and if glucose tolerance test may be useful as a diagnostic tool by predicting potential improvement of insulin sensitivity after biochemical cure of pHPT.

Full description

To be conducted at the Karolinska University Hospital, Stockholm. Patients with fb-glucos >6.1 and HbA1c without medical treatment will be included after informed consent and randomised to parathyroidectomy (PTX) within three months or not. The groups will be examined 4 ±4 weeks before and 12±2 weeks after PTX, similar for the control group. The number of participants will be estimated by power calculations based on a pilot study including 20 patients.

The test protocol includes glucose load with control of glucose and insulin, (0, 30, 60 and 120 min) together with measurement of markers of oxidative stress and inflammation.

Sex: All

Ages: 50+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• primary hyperparathyroidism and fb-glukos>6,1 and/or HbA1c > 39 mmol/mol

Exclusion criteria

• Treatment with insulin, sulfonylurea or metformin

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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0 participants in 2 patient groups

parathyroidectomy

Active Comparator group

Description:

change in insulin resistance

Treatment:

Procedure: parathyroidectomy

control

No Intervention group

Description:

the study participant will be examined parallel with the active comparator