Insulin Resistance in Type I Diabetes in Pediatric Care

Nationwide Children's Hospital

Status: Withdrawn

Conditions: Type 1 Diabetes

Treatments: Other: Clamp

Study type: Observational

Funder types: Other

Identifiers

NCT00946426

IRB09-00160

Details and patient eligibility

About

24 children (12 African-American, Hispanic, or American Indian, 12 Caucasian) previously diagnosed with type 1 diabetes mellitus will participate in this pilot study to evaluate the presence of hepatic and peripheral insulin resistance. The investigators will use this pilot information to test the hypothesis that insulin resistance occurs in some children with type 1 DM, is secondary to underlying risk factors, and is responsible for increased insulin needs. Methods will include a "step-up" hyperinsulinemic euglycemic clamp and infusion of the stable isotope 6,6-[2H2]-glucose. Patient and parent interviews will be conducted to gather information about nutritional intake, ethnicity, family history, and socioeconomic status. The investigators will also measure inflammatory cytokines and free fatty acids to determine whether they are associated with differences in insulin resistance among type 1 diabetes mellitus patients.

Sex: All

Ages: 9 to 23 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Previously diagnosed with type 1 diabetes
• ages 9 -11 tanner 1 or 16-23 tanner 4-5

Exclusion criteria

• None

Trial design

0 participants in 1 patient group

Diagnostic

Description:

Hyperinsulinemic euglycemic clamp

Treatment:

Other: Clamp