Insulin Resistance Indices and Coronary Artery Disease

Shiraz University of Medical Sciences

Status: Completed

Conditions: Coronary Artery Disease; Insulin Resistance

Treatments: Diagnostic Test: triglycerdie to HDL ratio; Diagnostic Test: triglyceride to glucose ratio

Study type: Observational

Funder types: Other

Identifiers

NCT06237244

IR.SUMS.MED.REC.1402.252

Details and patient eligibility

About

In this retrospective study from professor Kojuri clinic registry, total number of 1017 patients with first angiography were included and all data were recorded from registry. Insulin resistance was calculated using laboratory data

Full description

This was an analytical cross-sectional retrospective study involving patients with suspected CAD who underwent coronary angiography between December 2018 and May 2023. The information was obtained from patients referred to the outpatient cardiovascular clinic (Professor Kojuri Cardiology Clinic, Shiraz, Iran, www.kojuriclinic.com). Data was extracted from Professor Kojuri Cardiology Clinic database, including patient's information about the clinical history, presence or absence of specific diseases, angiography/angioplasty results, medications, and laboratory values.

A total of 14,708 patients who had undergone coronary angiography at least once were examined. After applying exclusion criteria, 1017 eligible cases were selected for data analysis.

The following data was recorded for the included patients: demographic data, past medical history (such as DM, hypertension, etc.), systolic and diastolic blood pressure, weight and height, fasting plasma glucose (FPG), hemoglobin A1c (HbA1c), total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and serum creatinine (Cr). Body mass index (BMI) was calculated as weight (Kg) divided by the square of height (m2). Obesity was defined as BMI ≥ 30 Kg/m2.

Laboratory values were selected from the time before angiography, and if not available, from the time shortly after the angiography. This helped us find those values which could best represent the metabolic state of patients at the time of angiography, while reducing the confounding effect of statin use.

Enrollment: 1,017 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients with age more than 18 years and having undergone coronary angiography

Exclusion criteria

• incomplete data
• history of prior coronary angiography or revascularization (percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG))
• serum creatinine > 1.4 mg/dL
• history of chronic kidney disease (CKD)
• cancer,

Trial design

1,017 participants in 2 patient groups

coronary artery disease

Description:

patients with coronary angiography of at least one vessel with more than 50% stenosis

Treatment:

Diagnostic Test: triglycerdie to HDL ratio

Diagnostic Test: triglyceride to glucose ratio

no coronary artery disease

Description:

patient with no stenosis in coronary angiography

Treatment:

Diagnostic Test: triglycerdie to HDL ratio

Diagnostic Test: triglyceride to glucose ratio