Insulin Sensitivity and Metabolism Before and After Treatment in Patients With Hypothyroidism

University of Aarhus

Status: Terminated

Conditions: Hypothyroidism

Treatments: Drug: Levothyroxin

Study type: Interventional

Funder types: Other

Identifiers

NCT00770016

LM_HYPO_2008

Details and patient eligibility

About

The aim of this study is to further characterize the treatment related changes in insulin sensitivity, substrate metabolism and intra hepatic- and intramyocellular lipid content in patients with hypothyroidism

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• written informed consent
• must be of legal age and competent
• Age > 18 years
• presently diagnosed with hypothyroidism

Exclusion criteria

• alcohol consumption >21 units per week
• Malignant disease
• pregnancy
• magnetic implants or material in the body
• BMI > 30
• Heart disease (NYHA >2)
• Uncontrolled hypertension
• Manifest diabetes mellitus
• Changes in medication, with any influence on glucose metabolism, 2 months prior to and until the end of the trial.

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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0 participants in 1 patient group

1

Experimental group

Description:

the aim of the present study is to characterize the treatment related changes in insulin sensitivity, substrate metabolism and intrahepatic - intramyocellular lipids in 12 adult patients, recently diagnosed with hypothyroidism

Treatment:

Drug: Levothyroxin